{"id":2,"date":"2017-05-08T09:40:36","date_gmt":"2017-05-08T09:40:36","guid":{"rendered":"http:\/\/vaccarilab.unimi.it\/?page_id=2"},"modified":"2022-01-24T17:49:17","modified_gmt":"2022-01-24T17:49:17","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/www.vaccarilab.unimi.it\/","title":{"rendered":"Welcome to the Vaccari lab website!"},"content":{"rendered":"<p>We are at the&nbsp;<a href=\"http:\/\/eng.dbs.unimi.it\/ecm\/home\">Department of Biosciences<\/a>&nbsp;of the&nbsp;<a href=\"http:\/\/www.unimi.it\/ENG\/\">University of Milan<\/a>, Italy.<\/p>\n<p>The Vaccari lab investigates fundamental questions concerning organ development and homeostasis, both in health and in disease, in particular in the context of <strong>tumorigenesis<\/strong> and rare and <strong>ultra-rare syndromes<\/strong>. We focus on the role of <strong>membrane trafficking <\/strong>and<strong> signal transduction<\/strong> in shaping and maintaining tissues and in preventing pathogenesis. Key signaling and trafficking regulators that we would like to know all about are \u2013 at the moment \u2013 <strong>Notch<\/strong>, the Endosomal Sorting Required for Transport (<strong>ESCRT<\/strong>) complex, the vacuolar-H+ ATPase (<strong>V-ATPase<\/strong>), the Soluble NSF Attachment Protein Receptors (SNAREs) <strong>Snap29<\/strong> and the transcription factor <strong>Mitf<\/strong>. We have a long standing interest in how these factors act in <strong>endocytosis, autophagy, lysosomal biogenesis <\/strong>and<strong> cell division<\/strong>. We use <strong>human cells in culture<\/strong> and the fruit fly <strong><em>Drosophila melanogaster<\/em><\/strong> as model systems to take our observations from the <em>subcellular<\/em> to <em>in vivo<\/em> level. We love to learn about how <strong>stem cells<\/strong> contribute to tissue formation and are masters of <strong>genetics<\/strong> and <strong>cell biology<\/strong>.<\/p>\n<p><span style=\"text-decoration: underline;\"><em>If you&#8217;d like to learn more about us, feel free to use the menu above and\/or to get in contact. We are always on the <a href=\"http:\/\/www.vaccarilab.unimi.it\/index.php\/contacts\/\">look out<\/a> for bright scientists and great collaborations. We are also passionate about engaging with the non scientist and explain what we do. <u>We&#8217;ll love to hear from you!<\/u><\/em><\/span><\/p>\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>We are at the&nbsp;Department of Biosciences&nbsp;of the&nbsp;University of Milan, Italy. The Vaccari lab investigates fundamental questions concerning organ development and homeostasis, both in health and in disease, in particular in the context of tumorigenesis and rare and ultra-rare syndromes. We &hellip; <a href=\"https:\/\/www.vaccarilab.unimi.it\/\">Continued<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"kt_blocks_editor_width":"","footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":27,"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":673,"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/pages\/2\/revisions\/673"}],"wp:attachment":[{"href":"https:\/\/www.vaccarilab.unimi.it\/index.php\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}