{"id":38,"date":"2017-05-09T16:29:05","date_gmt":"2017-05-09T16:29:05","guid":{"rendered":"http:\/\/vaccarilab.unimi.it\/?page_id=38"},"modified":"2024-12-30T16:24:59","modified_gmt":"2024-12-30T16:24:59","slug":"news","status":"publish","type":"page","link":"https:\/\/www.vaccarilab.unimi.it\/index.php\/news\/","title":{"rendered":"News"},"content":{"rendered":"\n

December 2024<\/strong><\/p>\n\n\n\n

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Francis<\/strong>, Luis<\/strong>, Alyssa <\/strong>and Francesco<\/strong> contributed to our understanding of how the receptor NOTCH1 is trafficked and activated in normal and cancer breast epitheliar cells. You can read the full study here<\/a>! <\/figcaption><\/figure>\n\n\n\n

August 2024<\/strong><\/p>\n\n\n\n

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We are happy to have been awarded a new Telethon grant<\/strong> to study in Drosophila Type B Kufs disease, a neuronal ceroid lipofuscinosis caused by mutations of Cathepsin F. Get in touch for more info!<\/figcaption><\/figure>\n\n\n\n

January 2024<\/strong><\/p>\n\n\n\n

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Paulien<\/strong> and Giuliana<\/strong> reviewed the literature regarding the toxic roles of dipeptide repeats expressed in the context of ALS. You can read the review here<\/a>!<\/figcaption><\/figure>\n\n\n\n

October 23<\/strong><\/p>\n\n\n\n

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Giulia Vitale<\/strong> is a new PhD candidate in the lab! After graduating in the lab in 2022 and a hiatus in a biotech, Giulia joined the lab for a second time to study the genetics and cell biology of CIPO with the support of Telethon Italia. Welcome back Giulia!<\/figcaption><\/figure>\n\n\n\n

September 23<\/strong><\/p>\n\n\n\n

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Antonio<\/strong> and Gaia<\/strong> have contributed to further our knowledge on the systemic effects of loss of fly NGL1, a gene mutated in a rare congenital disorders of glycosylation!<\/figcaption><\/figure>\n\n\n\n

August 23<\/strong><\/p>\n\n\n\n

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We are happy to be co-recipient with Seetharaman Parashuraman (CNR-IBBC, Naples, Italy)<\/a> of a PRIN2022PNRR grant from the Italian ministry of research (MUR)<\/strong> to study in Drosophila the role of glycans in tumorigenesis. Get in touch for more info!<\/figcaption><\/figure>\n\n\n\n

July 23<\/strong><\/p>\n\n\n\n

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We are happy to have been awarded a PRIN2022 grant from the Italian ministry of research (MUR)<\/strong> to study to further our study of intestinal pseudo-obstruction in Drosophila. Get in touch for more info!<\/figcaption><\/figure>\n\n\n\n

February 23<\/strong><\/p>\n\n\n\n

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We are happy to have been awarded a grant from Telethon Italia<\/strong> to study in Drosophila the genetics of intestinal pseudo-obstruction, a rare congenital syndome that impacts early life. We will open a position on this project soon. Get in touch for more info!<\/figcaption><\/figure>\n\n\n\n

December 22<\/strong><\/p>\n\n\n\n

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Deadline for application January 9 2023!<\/strong> Please get in touch for more info.<\/figcaption><\/figure>\n\n\n\n

November 22<\/strong><\/p>\n\n\n\n

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Shared work with the group of Maria Grazia Giansanti! <\/strong>Read about how GOLPH3 regulates mTOR signaling and autophagy. The first production of the collaborative work supported by the PRIN 2020 grant. <\/figcaption><\/figure>\n\n\n\n

September 22<\/strong><\/p>\n\n\n\n

Gaia is a new PhD candidate in Traslational Medicine! <\/strong><\/strong>She got out of the selection as 3nd out of many applicants and she will develop a project in collaboration with Elisa Borghi’s lab.<\/p>\n\n\n\n

August 22<\/strong><\/p>\n\n\n\n

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Collaborative work with the group of Angelo Poletti!<\/strong> Read about lysosomal damage and autophagy induction associated to Valosin mutations. A companion paper to our previous collaborative work (Rusmini et al 2019). <\/figcaption><\/figure>\n\n\n\n

July 22<\/strong><\/p>\n\n\n\n

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A fun collaboration with Davide Tampellini, Chiara Di Malta and Carmine Settembre!<\/strong> We find that TFEB is activated upon synaptic stimulation in models of Tauopaty relevant to Alzheimer and Parkinson disease. <\/figcaption><\/figure>\n\n\n\n

June 22<\/strong><\/p>\n\n\n\n

Francesco won the Ranzi award! <\/strong>Francesco’s master thesis on the generation and characterization of Drosophila mutants of the glycosylation gene Tusc3 was awarded the Ranzi prize for developmental biology. <\/p>\n\n\n\n

April 22<\/strong><\/p>\n\n\n\n

Giulia graduated! <\/strong>Giulia defended her Master thesis on the characterization of Drosophila Cathepsin F as a model of Type B Kufs disease earning top marks and honors! <\/p>\n\n\n\n

March 22<\/strong><\/p>\n\n\n\n

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Pauline’s review about Snap29 is out!<\/strong> An update from the lab on the many novel functions of the SNARE protein Snap29. A fun and engaging read. <\/figcaption><\/figure>\n\n\n\n

December 21<\/strong><\/p>\n\n\n\n

Gaia graduated! <\/strong>Gaia defended her Master thesis on the nutritional effects on the fitness of fly models of CDGs earning top marks and honors! <\/p>\n\n\n\n

October 21<\/strong><\/p>\n\n\n\n

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Our first PRIN! <\/strong>The lab got awarded a PRIN (Progetti di interesse nazionale – National Interest Projects) grant together with the group of MG Giansanti (CNR Rome) and G Callaini (Uni Siena). We are elated as this is the first time and PRIN is the only basic science grant in Italy (~10% funding rate). Cheers to 3 years support for SNAP29-related science!! <\/p>\n\n\n\n

September 21<\/strong><\/p>\n\n\n\n

Giuliana is a new PhD candidate in Molecular and Cellular Biology! <\/strong>She got out of the selection as 2nd out of 63 applicants and she will continue her project in collaboration with Simona Polo’s lab <\/p>\n\n\n\n

September 21<\/strong><\/p>\n\n\n\n

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Valentina Fajner’s paper is finally out!<\/strong> A tour de force characterization of a new gene that might be relevant to ALS pathogenesis<\/figcaption><\/figure>\n\n\n\n

July 21<\/strong><\/p>\n\n\n\n

Simona is a new PhD candidate in Translational Medicine! <\/strong>She got out of the selection as 5th out of 63 applicants and she will continue her project in collaboration with Valentina Massa <\/p>\n\n\n\n

April and June 21<\/strong><\/p>\n\n\n\n

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Simona and Francesco graduated! <\/strong>Welcome Dr. Totaro and Lavezzari! <\/p>\n\n\n\n

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18\/5\/21<\/strong><\/p>\n\n\n\n

Miriam PhD paper is out! <\/strong>In it we study autophagy and V-ATPase in a genetic model of glioma in Drosophila<\/em>!<\/p>\n\n\n\n

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31\/3\/21<\/strong><\/p>\n\n\n\n

A nice collaboration study with the group of Valentina Massa! <\/strong>We explored the microbiome of Drosophila<\/em> as a possible model of rare disease!<\/p>\n\n\n\n

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14\/1\/21<\/strong><\/p>\n\n\n\n

The last paper of the Snap29 trilogy by Elena and others in the lab has been accepted in Frontiers in cell and developmental biology<\/em>! <\/strong>In it, we describe the role of Snap29 in trafficking at the ER and Golgi compartments. <\/p>\n\n\n\n

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8\/12\/20<\/strong><\/p>\n\n\n\n

A nice collaboration with the group of Andrea Bassi at Polimi. <\/strong>Here we developed a nifty light sheet microscope connected to a microfluidic device for automated dual-color imaging of Drosophila<\/em> embryos! Link<\/a><\/p>\n\n\n\n

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20\/09\/20<\/strong><\/p>\n\n\n\n

China presented her work at MyDev2020<\/a>, the yearly meeting we co-organize with other labs interested in development in Milan, and got an honorable mention!<\/strong><\/p>\n\n\n\n

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28\/07\/20<\/strong><\/p>\n\n\n\n

The great work of Antonio, started in the lab of Hamed Jafar-Nejad and completed in the lab is finally out! <\/strong>Read about Dpp regulation and glycosylation and how this is relevant to patients affected by congenital disorders of glycosylation. Link<\/a><\/p>\n\n\n\n

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12\/12\/19<\/strong><\/p>\n\n\n\n

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Welcome Dr. Speranza<\/strong> – Elisa got her MSc. with top marks and honors<\/figcaption><\/figure>\n\n\n\n

12\/10\/19<\/strong><\/p>\n\n\n\n

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Winter lab pic. <\/strong>L to R: China, Elisa, Francesco, Francesca, Chiara, Giulia, Simona, Antonio, Federica, Th<\/figcaption><\/figure>\n\n\n\n

20\/07\/19<\/strong><\/p>\n\n\n

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Group photo with undergrads and summer students (Elisa Speranza – 3rd from left, the marvelous high schoolers from @CusMiBio<\/a> -5th and 7th from left and Tolgahan Ozer, Erasmus Program summer intern from Turkey- last from left)<\/figcaption><\/figure>\n<\/div>\n\n\n

18\/07\/19<\/strong><\/p>\n\n\n\n

Great collaborative work with the group of Valentina Massa UNIMI and others. In which we model aspects of the interactions that might be disrupted in Cornelia de Lange syndrome https:\/\/www.nature.com\/articles\/s41419-019-1792-x<\/a><\/p>\n\n\n\n

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05\/07\/19<\/strong><\/p>\n\n\n\n

A nice collaboration paper with the group of Stefano Biffo at INGM UNIMI. All about the phenotypic effects of ribosome assembly regulation by eIF6. If you can’t read it at https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0012160618307966?via%3Dihub<\/a> pls write to me for access. <\/p>\n\n\n\n

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28\/6\/19<\/strong><\/p>\n\n\n\n

We published a technical paper about analyzing ESCRT complexes in Drosophila. First work of talented master student Marco Gualtieri<\/a>, now a PhD student at Pasteur Institute in Paris. if you cannot read it at https:\/\/link.springer.com\/protocol\/10.1007%2F978-1-4939-9492-2_2<\/a> shoot me an email and I’ll send you a direct link!<\/p>\n\n\n\n

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1\/6\/19<\/strong><\/p>\n\n\n\n

We are now part of the ITN SAND<\/a> investigating unconventional secretion in neurodegeneration!<\/strong><\/p>\n\n\n\n

We have been awarded an European MSCA-ITN mega grant as the Italian unit of a consortium that aims at elucidating the role of trafficking in neurodegenation diseases. Read the details (in Italian) http:\/\/lastatalenews.unimi.it\/marie-s-curie-innovative-training-networks-finanziati-quattro-progetti-statale<\/a>. We are seeking an talented PhD student for enrollment in the fall. Details will come soon!<\/p>\n\n\n\n

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13\/2\/19<\/strong><\/p>\n\n\n\n

Antonio Galeone wins a Marie Curie Reintegration Fellowship to work in the lab on modeling rare CDG disease in fly! CONGRATS!!<\/p>\n\n\n\n

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Some press release about recent papers (in italian)<\/p>\n\n\n\n

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Tumori, da Milano nuove speranze per combattere il glioblastoma<\/a><\/blockquote>